Environmental factor dependent maximum likelihood method for association study targeted to personalized medicine.
نویسندگان
چکیده
The most challenging strategy for analyzing genome-wide polymorphisms and/or expression profiles is to solve multi-factor causal-relationship simultaneously. As the first step, we propose a framework of association study using maximum likelihood method that simultaneously handles genetic polymorphisms and epi-genetic information, e.g. environmental factors. We evaluate the theory by applying it to genotyped data of myocardial infarction (MI) patients.
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عنوان ژورنال:
- Genome informatics. Workshop on Genome Informatics
دوره 11 شماره
صفحات -
تاریخ انتشار 2000